Association Between Benzodiazepines and Dementia in South Korea: A Nation-Wide Study

Objective: Benzodiazepines are a widely used class of medications for anxiety, depression, and insomnia. Despite their common use, concerns remain about memory problems with benzodiazepines. the growing financial social burden dementia, inconsistent results persist regarding association between benzodiazepines dementia. Therefore, we aimed to evaluate dementia in Korea. Methods: Diagnostic prescription information from Health Insurance Review Assessment (HIRA) database South Korea 2009 2014 was utilized. The group included people who were diagnosed code received one or more prescriptions A total 68,241 participants 341,205 control matched. Possible confounders, such as major medical psychiatric disorders, adjusted, multivariate logistic regression conducted assess Results: highest odds ratio (OR) noted clonazepam (OR=2.86, 95% confidence interval [CI]=2.77–2.95) followed by those diazepam (OR=2.60, CI=2.53–2.66), lorazepam (OR=1.34, CI=1.30–1.37), triazolam (OR=1.26, CI=1.21–1.32). Conclusion: Overall, relatively long-acting benzodiazepines, clonazepam, diazepam, lorazepam, associated incidence Triazolam, which is approved insomnia, also significantly Individuals prescribed should be cautious loss Further studies needed confirm temporal biological causality